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1

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

Brett S. Carver, Caren Chapinski, John Wongvipat, Haley Hieronymus, Yu Chen, Sarat Chandarlapaty, Vivek K. Arora, Carl Le, Jason Koutcher, Howard Scher, Peter T. Scardino, Neal Rosen, Charles L. Sawye

Journal:

Year:

2011

Language:

english

File:

PDF, 1.64 MB

english, 2011

2

O

DeFotis, G. C., Coffey, G. A., Cinquina, C. C., Chandarlapaty, S., Brubaker, W. W., Krovich, D. J., Chamberlain, R. V., Jarvis, W. R. A.

Journal:

Physical Review B

Year:

1995

Language:

english

File:

PDF, 747 KB

english, 1995

3

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

Schiavon, G., Hrebien, S., Garcia-Murillas, I., Cutts, R. J., Pearson, A., Tarazona, N., Fenwick, K., Kozarewa, I., Lopez-Knowles, E., Ribas, R., Nerurkar, A., Osin, P., Chandarlapaty, S., Martin, L.-

Journal:

Science Translational Medicine

Year:

2015

Language:

english

File:

PDF, 361 KB

english, 2015

4

Ash1, a Daughter Cell-Specific Protein, Is Required for Pseudohyphal Growth of Saccharomyces cerevisiae

Chandarlapaty, Sarat, Errede, Beverly

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.57 MB

english, 1998

5

In Defense of Tradition: Mohammed Mrabet's Postcolonial Leaningsand the Confrontation of "Kif Wisdom" with Modernity

Raj Chandarlapaty

Journal:

Storytelling Self Society An Interdisciplinary Journal of Storytelling Studies

Year:

2007

Language:

english

File:

PDF, 1.58 MB

english, 2007

6

Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients

Ross, D.S., Liu, B., Schram, A.M., Razavi, P., Lagana, S.M., Zhang, Y., Scaltriti, M., Bromberg, J.F., Ladanyi, M., Hyman, D.M., Drilon, A., Zehir, A., Benayed, R., Chandarlapaty, S., Hechtman, J.F.

Journal:

Annals of Oncology

Year:

2020

File:

PDF, 772 KB

2020

7

Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth

Chandarlapaty, S, Scaltriti, M, Angelini, P, Ye, Q, Guzman, M, Hudis, C A, Norton, L, Solit, D B, Arribas, J, Baselga, J

Journal:

Year:

2009

Language:

english

File:

PDF, 639 KB

english, 2009

8

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

Serra, V, Scaltriti, M, Prudkin, L, Eichhorn, P J A, Ibrahim, Y H, Chandarlapaty, S, Markman, B, Rodriguez, O, Guzman, M, Rodriguez, S

Journal:

Year:

2011

Language:

english

File:

PDF, 771 KB

english, 2011

9

Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer

Chandarlapaty, S.

Journal:

Cancer Discovery

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

10

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Sarat Chandarlapaty, Ayana Sawai, Maurizio Scaltriti, Vanessa Rodrik-Outmezguine, Olivera Grbovic-Huezo, Violeta Serra, Pradip K. Majumder, Jose Baselga, Neal Rosen

Journal:

Year:

2011

Language:

english

File:

PDF, 1.95 MB

english, 2011

11

HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies

Gajria, Devika, Chandarlapaty, Sarat

Journal:

Expert Review of Anticancer Therapy

Year:

2011

Language:

english

File:

PDF, 1.64 MB

english, 2011

12

Noninvasive diagnosis of left ventricular pseudoaneurysm by radioangiography and echography

Barry R Alter, Michael E Lewis, Abelardo Vargas, Stephen P Rosenthal, S.K.C Chandarlapaty

Journal:

American Heart Journal

Year:

1981

Language:

english

File:

PDF, 2.46 MB

english, 1981

13

Sequential internal mammary artery grafts for coronary artery bypass

George M. Palatianos, Hooshang Bolooki, Michael D. Horowitz, Maureen H. Lowery, Stephen P. Rosenthal, S.K.C. Chandarlapaty, George N. Sfakianakis, Gerard A. Kaiser

Journal:

The Annals of Thoracic Surgery

Year:

1993

Language:

english

File:

PDF, 912 KB

english, 1993

14

544 POSTER SNX5542, an oral Hsp90 inhibitor, causes Her2 degradation and inhibition of tumor growth in models of Her2 amplified breast cancer.

S. Chandarlapaty, Q. Ye, K. Huang, P. Fadden, N. Rosen, D. Solit

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

15

A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors

Hudis, Clifford, Swanton, Charles, Janjigian, Yelena Y, Lee, Ray, Sutherland, Stephanie, Lehman, Robert, Chandarlapaty, Sarat, Hamilton, Nicola, Gajria, Devika, Knowles, James, Shah, Jigna, Shannon, K

Journal:

Breast Cancer Research

Year:

2013

Language:

english

File:

PDF, 622 KB

english, 2013

16

A Phase II Open-Label Study of Ganetespib, a Novel Heat Shock Protein 90 Inhibitor for Patients With Metastatic Breast Cancer

Jhaveri, Komal, Chandarlapaty, Sarat, Lake, Diana, Gilewski, Teresa, Robson, Mark, Goldfarb, Shari, Drullinsky, Pamela, Sugarman, Steven, Wasserheit-Leiblich, Carolyn, Fasano, Julie, Moynahan, Mary El

Journal:

Clinical Breast Cancer

Year:

2014

Language:

english

File:

PDF, 438 KB

english, 2014

17

PTEN is a protein tyrosine phosphatase for IRS1

Shi, Yuji, Wang, Junru, Chandarlapaty, Sarat, Cross, Justin, Thompson, Craig, Rosen, Neal, Jiang, Xuejun

Journal:

Nature Structural and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

18

417 A Mechanistic Logic for Dual Targeting of HER2 and PI3K/AKT/mTOR Signaling in HER2 Amplified Breast Cancer

Chandarlapaty, S., Rodrik-Outmezguine, V., Scaltriti, M. Maurizio, Sakr, R., Will, M., Giri, D., Hudis, C., Baselga, J., King, T., Rosen, N.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 64 KB

english, 2012

19

367 BAY80-6946 is a Potent and Selective PI3K Inhibitor That Induces Apoptosis in Breast Cancers by Blocking AKT and Non-AKT PI3K Effector Pathways

Will, M., Toy, W., Payal, P., Rodrik-Outmezguine, V., Schneider, C., Paul, J., Liu, N., Rosen, N., Chandarlapaty, S.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 62 KB

english, 2012

20

Molecular Pathways: HER3 Targeted Therapy

Gala, K., Chandarlapaty, S.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.62 MB

english, 2014

21

Acute Renal Failure Due to Rhabdomyolysis Associated With the Extreme Lithotomy Position

Ali, Hassan, Nieto, José G., Rhamy, Robert K., Chandarlapaty, S.K.C., Vaamonde, Carlos A.

Journal:

American Journal of Kidney Diseases

Year:

1993

Language:

english

File:

PDF, 791 KB

english, 1993

22

Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guideline

Ramakrishna, N., Temin, S., Chandarlapaty, S., Crews, J. R., Davidson, N. E., Esteva, F. J., Giordano, S. H., Gonzalez-Angulo, A. M., Kirshner, J. J., Krop, I., Levinson, J., Modi, S., Patt, D. A., Pe

Journal:

Journal of Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 114 KB

english, 2014

23

[IEEE 2007 25th International Conference on Computer Design ICCD 2007 - Lake Tahoe, CA, USA (2007.10.7-2007.10.10)] 2007 25th International Conference on Computer Design - LEMap: Controlling leakage in large chip-multiprocessor caches via profile-guided virtual address translation

Chandarlapati, Jugash, Chaudhuri, Mainak

Year:

2007

Language:

english

File:

PDF, 398 KB

english, 2007

24

Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer

Chandarlapaty, S., Sakr, R. A., Giri, D., Patil, S., Heguy, A., Morrow, M., Modi, S., Norton, L., Rosen, N., Hudis, C., King, T. A.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 990 KB

english, 2012

25

Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline

Giordano, S. H., Temin, S., Kirshner, J. J., Chandarlapaty, S., Crews, J. R., Davidson, N. E., Esteva, F. J., Gonzalez-Angulo, A. M., Krop, I., Levinson, J., Lin, N. U., Modi, S., Patt, D. A., Perez,

Journal:

Journal of Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 167 KB

english, 2014

26

Ferromagnetism of single crystal Fe[S2CN(C2D5)2]2Cl

DeFotis, G. C., Brubaker, W. W., Chandarlapaty, S., Beers, K. L., Coffey, G. A .

Journal:

Journal of Applied Physics

Year:

1994

Language:

english

File:

PDF, 639 KB

english, 1994

27

Concentration-dependent critical behavior in dilute ferromagnetic Fe1−xAsx[S2CN(C2H5)2]2Cl

DeFotis, G. C., Coffey, G. A., Coker, G. S., Marmorino, J. L., Beers, K. L., Chandarlapaty, S., Brubaker, W. W., Pugh, V. J., Carling, S. A., Day, P.

Journal:

Journal of Applied Physics

Year:

1996

Language:

english

File:

PDF, 362 KB

english, 1996

28

PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ--Implications for Progression to Invasive Breast Carcinoma

Sakr, R. A., Weigelt, B., Chandarlapaty, S., Andrade, V. P., Guerini-Rocco, E., Giri, D., Ng, C. K. Y., Cowell, C. F., Rosen, N., Reis-Filho, J. S., King, T. A.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.59 MB

english, 2014

29

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase Dependent Cancers

Chandarlapaty, S., Sawai, A., Ye, Q., Scott, A., Silinski, M., Huang, K., Fadden, P., Partdrige, J., Hall, S., Steed, P., Norton, L., Rosen, N., Solit, D. B.

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 642 KB

english, 2008

30

Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor

Scaltriti, M., Chandarlapaty, S., Prudkin, L., Aura, C., Jimenez, J., Angelini, P. D., Sanchez, G., Guzman, M., Parra, J. L., Ellis, C., Gagnon, R., Koehler, M., Gomez, H., Geyer, C., Cameron, D., Arr

Journal:

Clinical Cancer Research

Year:

2010

Language:

english

File:

PDF, 494 KB

english, 2010

31

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

Rodrik-Outmezguine, V. S., Chandarlapaty, S., Pagano, N. C., Poulikakos, P. I., Scaltriti, M., Moskatel, E., Baselga, J., Guichard, S., Rosen, N.

Journal:

Cancer Discovery

Year:

2011

Language:

english

File:

PDF, 5.43 MB

english, 2011

32

Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS-ERK Signaling

Will, M., Qin, A. C. R., Toy, W., Yao, Z., Rodrik-Outmezguine, V., Schneider, C., Huang, X., Monian, P., Jiang, X., de Stanchina, E., Baselga, J., Liu, N., Chandarlapaty, S., Rosen, N.

Journal:

Cancer Discovery

Year:

2014

Language:

english

File:

PDF, 5.07 MB

english, 2014

33

Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel

Sawai, A., Chandarlapaty, S., Greulich, H., Gonen, M., Ye, Q., Arteaga, C. L., Sellers, W., Rosen, N., Solit, D. B.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 660 KB

english, 2008

34

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients

Scaltriti, M., Eichhorn, P. J., Cortes, J., Prudkin, L., Aura, C., Jimenez, J., Chandarlapaty, S., Serra, V., Prat, A., Ibrahim, Y. H., Guzman, M., Gili, M., Rodriguez, O., Rodriguez, S., Perez, J., G

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 646 KB

english, 2011

35

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

Modi, S., Stopeck, A., Linden, H., Solit, D., Chandarlapaty, S., Rosen, N., D'Andrea, G., Dickler, M., Moynahan, M. E., Sugarman, S., Ma, W., Patil, S., Norton, L., Hannah, A. L., Hudis, C.

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

36

Targeted Therapy for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Can There Be Too Many Active Drugs?

Chandarlapaty, S., Modi, S.

Journal:

Journal of Clinical Oncology

Year:

2011

Language:

english

File:

PDF, 152 KB

english, 2011

37

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer

Janiszewska, Michalina, Liu, Lin, Almendro, Vanessa, Kuang, Yanan, Paweletz, Cloud, Sakr, Rita A, Weigelt, Britta, Hanker, Ariella B, Chandarlapaty, Sarat, King, Tari A, Reis-Filho, Jorge S, Arteaga,

Journal:

Nature Genetics

Year:

2015

Language:

english

File:

PDF, 5.08 MB

english, 2015

38

Biomarkers that Predict Sensitivity to Heat Shock Protein 90 Inhibitors (HSP90i)

Jhaveri, Komal, Chandarlapaty, Sarat, Iyengar, Neil, Morris, Patrick G., Corben, Adriana D., Patil, Sujata, Akram, Muzaffar, Towers, Russell, Sakr, Rita A., King, Tari A., Norton, Larry, Rosen, Neal,

Journal:

Clinical Breast Cancer

Year:

2015

Language:

english

File:

PDF, 1.65 MB

english, 2015

39

Influence of Heparin on Serum Free Thyroxine 1

SCHATZ, DOUGLAS L., SHEPPARD, ROBERT H., STEINER, GEORGE, CHANDARLAPATY, CHAITANYA S., DEVEBER, GEORGE A.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1969

Language:

english

File:

PDF, 906 KB

english, 1969

40

Working-Class Literature || The Bop Apocalypse: The Religious Visions of Kerouac, Ginsberg and Burroughsby John Lardas

Review by: Raj Chandarlapaty

Journal:

College Literature

Year:

2002

Language:

english

File:

PDF, 360 KB

english, 2002

41

Detection of HER2-positive metastases in patients with HER2-negative primary breast cancer using the 89Zr-DFO-trastuzumab PET/CT

Ulaner, G. A., Hyman, D., Ross, D., Corben, A., Chandarlapaty, S., Goldfarb, S., McArthur, H., Erinjeri, J., Solomon, S., Kolb, H., Lyashchenko, S., Lewis, J., Carrasquillo, J.

Journal:

Journal of Nuclear Medicine

Year:

2016

Language:

english

File:

PDF, 870 KB

english, 2016

42

Consensus on precision medicine for metastatic cancers: a report from the MAP conference: Table 1.

Swanton, C., Soria, J.-C., Bardelli, A., Biankin, A., Caldas, C., Chandarlapaty, S., de Koning, L., Dive, C., Feunteun, J., Leung, S.-Y., Marais, R., Mardis, E. R., McGranahan, N., Middleton, G., Quez

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 108 KB

english, 2016

43

A New Approach to Parathyroidectomy

Irvin, George L., Prudhomme, David L., Deriso, George T., Sfakianakis, George, Chandarlapaty, S. K.C.

Journal:

Annals of Surgery

Year:

1994

File:

PDF, 2.44 MB

1994

44

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients

Maurizio Scaltriti, Pieter J. Eichhorn, Javier Cortés, Ludmila Prudkin, Claudia Aura, José Jiménez, Sarat Chandarlapaty, Violeta Serra, Aleix Prat, Yasir H. Ibrahim, Marta Guzmán, Magui Gili, Olga Rod

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

45

Gallium Uptake in a Paraplegic Patient with Bilateral Lower Extremity Fat Necrosis

WOLPE, FRANCINE M., CHANDARLAPATY, S K C, JACOBI, JORGE D., WELLS, MARILYN, ROSENTHAL, STEPHEN

Journal:

Clinical Nuclear Medicine

Year:

1989

File:

PDF, 101 KB

1989

46

Weekly paclitaxel with trastuzumab and pertuzumab in patients with HER2-overexpressing metastatic breast cancer: overall survival and updated progression-free survival results from a phase II study

Smyth, L. M., Iyengar, N. M., Chen, M. F., Popper, S. M., Patil, S., Wasserheit-Lieblich, C., Argolo, D. F., Singh, J. C., Chandarlapaty, S., Sugarman, S. M., Comen, E. A., Drullinsky, P. R., Traina,

Journal:

Breast Cancer Research and Treatment

Year:

2016

Language:

english

File:

PDF, 794 KB

english, 2016

47

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario

Journal:

Year:

2016

Language:

english

File:

PDF, 3.70 MB

english, 2016

48

Exercise and Prognosis on the Basis of Clinicopathologic and Molecular Features in Early Stage Breast Cancer: The LACE and Pathways Studies

Jones, L. W., Kwan, M. L., Weltzien, E. K., Chandarlapaty, S., Sternfeld, B., Sweeney, C., Bernard, P. S., Castillo, A. L., Habel, L. A., Kroenke, C. H., Langholz, B. M., Quesenberry, C. P., Dang, C.

Journal:

Cancer Research

Year:

2016

Language:

english

File:

PDF, 707 KB

english, 2016

49

Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer

Chandarlapaty, Sarat, Chen, David, He, Wei, Sung, Patricia, Samoila, Aliaksandra, You, Daoqi, Bhatt, Trusha, Patel, Parul, Voi, Maurizio, Gnant, Michael, Hortobagyi, Gabriel, Baselga, José, Moynahan,

Journal:

Year:

2016

Language:

english

File:

PDF, 398 KB

english, 2016

50

Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence

Yang, C, Li, Z, Bhatt, T, Dickler, M, Giri, D, Scaltriti, M, Baselga, J, Rosen, N, Chandarlapaty, S

Journal:

Year:

2016

Language:

english

File:

PDF, 2.47 MB

english, 2016